ULB, CHU Saint-Pierre, Hôpital Erasme, ULiège - FNRS

" The project investigates the immune responses to SARS-CoV-2 infection in humans. Cohorts of patients and contacts are recruited and followed-up during several months following infection. Using systems serology and systems biology approaches, the quality and dynamics of antibody and cellular responses are analysed to identify correlates of protection against severe disease and to determine the duration of natural immunity to the virus. The project should provide insight in the host response to SARS-CoV-2 and should help define deconfinement strategies and develop prophylactic and therapeutic interventions against COVID-19. "
Funding: COVID 19 - ULB
Contact: Arnaud Marchant: This email address is being protected from spambots. You need JavaScript enabled to view it. Stanislas Goriely: This email address is being protected from spambots. You need JavaScript enabled to view it.

ULB, Bordet Institute and CHU Saint-Pierre
" The limited capacity of intensive care unit (ICU) beds and the high mortality of patients requiring ICU care after COVID-19 infection are major problems that urgently require solutions. Early evidence suggests that an individual patient's immune responses to this virus are a key factor in their disease pathogenesis. This response can be further compounded by underlying factors, which for patients at Bordet can be exacerbated by their cancer status. A recent study shows that some cancer patients (particularly lung, blood or metastatic cancer patients) are three times more likely to die from COVID-19 infection. Thus, there is an important need to understand and identify immune biomarker(s) that measure functionality of innate and/or adaptive immunity in the blood with rapid turnaround to provide much needed information for clinical decision making. The anticipated results of this collaborative research project include the identification of...

Read more: Ahmad Awada, Chef de Service, Medical Oncology - Karen Willard-Gallo, Laboratory Head, Molecular...

UMONS/ Haute école Condorcet/ UCLouvain/ Epicura/ Machine sight
" In view of the risk of a respirator shortage in intensive care units throughout the world following the COVID 19 epidemic, a simple solution based on existing means or means that are easy to implement is being sought by a consortium of respiratory physiotherapists, researchers of UMONS, physicians of the the intensive care unit of the Epicura hospital and a mechatronics engineering company. In view of the risk of a respirator shortage in intensive care units throughout the world following the COVID 19 epidemic, a simple solution based on existing means or means that are easy to implement is being sought by a consortium of respiratory physiotherapists, researchers of UMONS, physicians of the the intensive care unit of the Epicura hospital and a mechatronics engineering company. "
Funding: internal funding
Contact: Pr. Alexandre Legrand, head of the laboratory of Physiology and Respiratory Rehabilitation...

Read more: Alexandre Legrand, Professor

Institut Jules Bordet
" Contribution to the application and implementation of a novel Covid-19 diagnostic testing method developed at the GIGA/FARAH academic research institutes. Starting with a handful academic scientists from different disciplines, we established a Covid diagnostic lab with the goal of increasing the testing capacity in Belgium during the heaviest period of the crisis. The lab was entirely and exclusively build by training academic volunteers dedicating their time and energy to a joint effort to "beat the virus". Today the lab has a testing capacity of > 3000 samples/day, 7days/7. The diagnostic lab contributed - and still contributes - to the federal Testing Task Force as one of the five partners involved in screening nursing homes and more recently "centres de triage". We believe extensive testing may be critical to assist and better understand the nascent "deconfinement". Making available our expertise in virus-associated diseases accumulated over years of...

Read more: Anne Van den Broeke, Doctor

UCLouvain, Cliniques universitaires Saint-Luc - FNRS
" "Telomeres are non-coding DNA sequences located at the end of chromosomes. In highly dividing cells, like embryonic stem cells and germ cells, telomeres are maintained by the telomerase complex. In the absence of telomerase activity in normal somatic cells, telomeres shorten after each cell division, ultimately leading to cell senescence or apoptosis. Telomeres are thus considered as ""molecular biological clocks"", closely related to ageing. Short telomeres syndromes (STS) have been identified, that are linked to genetic mutations affecting compounds of the telomerase complex, or proteins with crucial roles in telomere protection, and resulting in various conditions including lung fibrosis and aplastic anaemia (1). Bone marrow failure in STS results from the premature exhaustion of hematopoietic stem cells and, overall, tissues from STS patients suffer from premature senescence that likely drives the organ failures...

Read more: Antoine FROIDURE, Professor - Jean-Philippe DEFOUR, Professor - Anabelle DECOTTIGNIES, FNRS Senior...

UCLouvain and Cliniques universitaires Saint-Luc - FNRS
" Anosmia has been reported to be a major symptom of COVID-19. Since high viral loads are found in the nasal cavity of patients and since single-cell analyses found that olfactory sustentacular and stem cells highly express ACE2 and TMPRSS2, it is suspected that cells of the olfactory neuroepithelium are a preferred target of the virus. Some COVID-19 patients present with neurological symptoms. Interestingly, it has been reported that the former SARS-CoV, can ascend intracranially, possibly via the olfactory nerves. Since olfactory receptor neurons form a direct connection between the nasal cavity and the brain, we hypothesize that these cells act as a gateway towards the brain in some patients. The main aims of the projects are (1) to investigate the pathophysiology of COVID-related olfactory dysfunction and (2) to investigate whether olfactory receptor neurons could be the entry site of SARS-CoV2 to the brain. "
Funding...

Read more: Caroline Huart, MD, PhD - Bernard Hanseeuw, MD, PhD - Valérie Hox, MD, PhD - Pascal...

UCLouvain, St-Luc
" We aim to characterize the reprogramming of structural cells of the lungs that are direct targets of the SARS-CoV-2, namely type 2 alveolar epithelial cells and endothelial cells, as well as their potential role in the induction of the (hyper)inflammatory phase of the disease leading to acute lung injury. The skills of our laboratory in lung and mucosal immunology research that are relevant to this field are (1) access to precious human lung tissue (e.g. from SARS-CoV-2 patients), (2) multiplex immunofluorescence staining and isolation of structural cells (e.g. alveolar epithelial cells, endothelial cells) from the human lung, as well as (3) their characterization using cell culture-based readouts and (in collab. with the UCL-CTMA) genetic sequencing. "
Funding: FNRS CUR, application submitted on 01-05-20.
Publication References: 1. Gohy ST, Hupin C, Fregimilicka C, Detry BR, Bouzin C, Gaide Chevronay H, Lecocq M, Weynand B, Ladjemi MZ, Pierreux CE, Birembaut P...

Read more: Charles Pilette, Professor

Institut Jules Bordet, ULB - FNRS
" Cancer patients under active treatment are thought to be highly vulnerable with regards to the current pandemic of COVID-19 disease. Their management has drastically changed over the past weeks, as clinics have been forced to adapt their care strategies according to national guidelines, postponing all non-essential consultations and having patients avoid the clinic altogether as much as possible. However, it is currently unclear if cancer patients are indeed at a higher risk of developing COVID-19 disease, and if systemic oncological treatment contributes to more severe disease because of suppression of the immune system, or rather protects against fatal cytokine release storms and acute respiratory distress syndromes. This information is absolutely crucial for the safety assessment of using cancer treatments during the COVID-19 pandemic, and for the monitoring of cancer patients during this period. Therefore, this project is a non-interventional...

Read more: Christos Sotiriou, FNRS Research Director

Erasme Hospital
" Objectifs : L'épidémie du coronavirus a eu des conséquences délétères sur la santé mentale de la population générale1,2. Aucune étude ne s'est encore penchée sur l'impact psychologique du coronavirus sur les proches des patients ayant été infectés par le covid-19. Cette étude permet de comparer les proches de patients survivants ayant séjourné ou n'ayant pas séjourné en soins intensifs, des proches de patients décédés. Méthodologie : Les familles (N=200) dont le proche a séjourné en soins intensifs ou en unité COVID à l'hôpital Erasme seront contactées par téléphone et invitées à compléter des questionnaires en ligne au minimum 1 mois après la sortie d'hospitalisation de leur proche, ou après son décès, et ensuite 6 mois après la première évaluation. Les variables psychologiques qui seront évaluées sont : (1) la qualité de vie (The Mc Gill Quality of Life Questionnaire), les symptômes anxieux et dépressifs (Hospital Anxiety and Depression Scale, HADS), les...

Read more: Delphine Canivet, PhD

ULiège, CHU de Liège, CIRM
" This study aims at measuring the activity of the Angiotensin-2 enzyme (AT2) by LCMS./MS in COVID patients. This enzyme plays a key-role in the mechanisms of the infection by the SARS-COV2 "
Funding: Fondation Leon Fredericq
Contact: Professor Etienne Cavalier Department of Clinical Chemsitry University of Liège, CHU de Liège This email address is being protected from spambots. You need JavaScript enabled to view it.

ULiege, CHU, GIGA I3
" Are obstructive diseases risk factors for developing pulmonary complications due to COVID19? We will include all patients followed up at CHU of Liege for COVID19 infection and classify them according to their underlying bronchopulmonary disease. The aim is to evaluate if asthma, severe asthma or chronic obstructive pulmonary diseases represent risk factors for developing pulmonary complications during COVID 19 infection. We want to find out biological or clinical predictors of complications. We also want to evaluate efficacy and safety of inhaled corticosteroids in asthma in case of COVID infection. Biomarkers will be measured at baseline and during follow-up. "
Funding: Fonds Leon Frederic
Contact: Schleich Florence, MD, PhD This email address is being protected from spambots. You need JavaScript enabled to view it. This email address is being protected from spambots. You need JavaScript enabled to view it.

ULiège - FNRS
" L'atteinte rénale semble fréquente et précoce dans la COVID-19. Sa physiopathologie est inconnue. Le but de cette étude est de caractériser cette néphropathie nouvelle causée par le SRAS-Cov-2. Nous réalisons une biopsie rénale post mortem chez tout patient décédé dans le cadre d'une infection COVID-19 en salle d'hospitalisation ou aux soins intensifs (SI). L'étude se focalise sur la corrélation anatomo-clinique. L'étude histologique inclut (i) une description conventionnelle des compartiments glomérulaire, tubulaire et interstitiel ; (ii) une détection immuno-histochimique des antigènes viraux du SRAS-Cov-2 et leur distribution préférentielle dans chaque segment du néphron ; (iii) une caractérisation de l'infiltrat inflammatoire éventuel ; et (iv) une microscopie électronique. "
Funding: Fondation Léon Frédéricq ULiège (21.600 euros) FNRS (en attente) Société Francophone de Néphrologie (en attente)
Contact: Pr dr François JOURET Centre Hospitalier de l'Université de...

Read more: François JOURET, Professeur - Pierre Delanaye, Professeur - Jean-Marie Krzesinski, Professeur...

UCLouvain, CHU UCLouvain/UNamur
" Evaluation of the thrombotic risk associated with SARS-CoV-2 infection and its management in the intensive care unit: a clinical and biological longitudinal study. Background Since the beginning of SARS-CoV-2 outbreak in December 2019, data accumulate regarding the high thrombotic risk associated with this infection, which could explain substantial part of the observed morbidity and mortality (1). Accordingly, a retrospective study suggested that prophylactic anticoagulation could reduce mortality in severe COVID-19 patients with sepsis-induced coagulopathy (2). Furthermore, a European cohort reported a 27% incidence of venous thrombo-embolisms (VTEs) despite systematic prophylactic anticoagulation, raising the question whether deeper anticoagulant regimen would be beneficial in severe COVID-19 (3). Some authors also suggested that fibrinolysis alterations could be a significant determinant of SARS-CoV-2 infection's prognosis, as it is in...

Read more: Francois Mullier, Prof - Alain Dive, Prof - Michael Hardy, Dr - Sarah Lessire, Prof - Isabelle...

Hôpital Erasme and ULB - Faculty of medicine
" A translational prospective research project was initiated to characterize longitudinally the immune responses of patients with COVID-19, to identify the mechanisms underlying progression to severe disease. Blood samples are collected at three different time points from two groups of patients, those with a flu-like disease, and those with respiratory symptoms (mild to severe). They are stored in a biobank after appropriate treatment to be further available for different research projects. The first one will focus on the characterization of the phenotype of innate cells (dendritic cells, monocytes, NK cells) and T lymphocyte subpopulations, and on the analysis of the concentrations of IFN-a and a panel of other cytokines, to investigate the importance of the kinetic of pDC mobilization and type I IFN production before the appearance of the cytokine storm. "
Funding: - ULB - COVID-19 special call - FNRS - crédit urgent de recherche...

Read more: Françoise Mascart, Professor - Véronique Del Marmol, Professor - Véronique Corbière, Doctor

Cliniques universitaires Saint-Luc - UCLouvain - FRIA - FNRS
FD and CH are members of the cliniques universitaires Saint-Luc (CUSL). CD is a postdoctoral researcher at UCLouvain. AC is a PhD Fellow of the Belgian Fonds pour la Formation à la Recherche dans l'Industrie et dans l'Agriculture (FRIA). PS is a Senior Research Associate of the Fonds National de la Recherche Scientifique (F.R.S-FNRS). - FNRS

" The novel coronavirus infection (COVID-19) is a global public health emergency. In several months, the infection has spread dramatically to the entire world and resulted in a major epidemic. In this context, pregnant women require particular attention in term of emerging infections because of the physiological changes in their immune and cardiopulmonary systems. The first analysis of 38 pregnant women with COVID-19 is quite reassuring since it did not report any maternal deaths, increased complications or vertical transmission. However, specific prospective studies about...

Read more: Frédéric Debiève, Professor (MD, PhD) - Arthur Colson, PhD fellow (MD) - Christophe Depoix,...