ULB
" Developing a platform for systems serology analysis of SARS-CoV-2 infection. Sarra Ait Djebbara and Pascale Deblandre are contributing to this project developped by Prof. Arnaud Marchant (IMI - ULB) "
Funding: FNRS
Contact: Lab of Parasitology - Faculty of Medicine - ULB Erasmus Campus
ULB
"Our objectives are: • To study maternal and neonate COVID-19 information in the Belgian-Obstetric Surveillance System database: clinical presentation and natural history of disease, pregnancy-related basic information, pregnancy outcomes, birth characteristics, infant morbidity and mortality. • To study the core socio-demographic information to potentially identify groups at higher risk of complications • Build a more informative dataset thanks to data mining of public databases This study will enable us to understand the impact of COVID-19 on pregnant women and their offspring in Belgium, and in the world via the contribution to the INOSS multicenter study. It might allow us to define an at-risk population among pregnant women and their offspring, and tailor epidemiologic and clinical interventions for these more vulnerable individuals."
Funding: Pending (FNRS)
Publication References: "1. The International Network of Obstetric Survey Systems study of uterine rupture: a...
ULB
" COVerT Our aim is to delineate more accurately the prevalence of the infection in the pregnant population and study vertical transmission in the cord blood of babies born to mothers with confirmed SARS-CoV-2 infection. Determination of prevalence of SARS-CoV-2 infection in mothers by combined universal screening: presence of antibodies (IgG and IgM or IgA) in their blood and/or a positive RT-PCR in the nasopharyngeal swab. We intend to detect evidence of vertical transmission by the identification of SARS-CoV-2 specific IgM or IgA in cord blood samples. If there is evidence of vertical transmission, the analysis of the consequences depending on infection timing during pregnancy will enable us to guide management more precisely. "
Funding: pending FNRS
Publication References: "1. Delforge ML, Costa E, Brancart F, Goldman D, Montesinos I, Zaytouni S, Marchant A, Donner C Presence of cytomegalovirus in urine and blood of pregnant women with primary infection might be associated...
UCLouvain and Cliniques universitaires Saint-Luc - FNRS
" Anosmia has been reported to be a major symptom of COVID-19. Since high viral loads are found in the nasal cavity of patients and since single-cell analyses found that olfactory sustentacular and stem cells highly express ACE2 and TMPRSS2, it is suspected that cells of the olfactory neuroepithelium are a preferred target of the virus. Some COVID-19 patients present with neurological symptoms. Interestingly, it has been reported that the former SARS-CoV, can ascend intracranially, possibly via the olfactory nerves. Since olfactory receptor neurons form a direct connection between the nasal cavity and the brain, we hypothesize that these cells act as a gateway towards the brain in some patients. The main aims of the projects are (1) to investigate the pathophysiology of COVID-related olfactory dysfunction and (2) to investigate whether olfactory receptor neurons could be the entry site of SARS-CoV2 to the brain. "
Funding...
Read more: Caroline Huart, MD, PhD - Bernard Hanseeuw, MD, PhD - Valérie Hox, MD, PhD - Pascal...
UCLouvain
" Confinement constitutes a particular life event involving multiple adaptations in daily life. The purposes of this study are (1) to analyze how adults manage these modifications concerning the possible practice of physical activities, (2) to better understand the changes in the practice of physical activities as a lifelong health behavior in adults. The principal models used are the Health action process approach model (Schwarzer, 2008), health literacy and the social support theory. 272 adults completed a questionnaire about their PA before and during confinement. Respondents who agreed to be contacted will complete a post-containment survey to evaluate the persistence of the modifications in term of adoption of APS as a health behavior "
Funding: In process
Contact: IACCHOS (Girsef) - FSM Cécile Delens Place Pierre de Coubertin, 1 bte L8.10.01 - 1348 Louvain-la-Neuve This email address is being protected from spambots. You need JavaScript enabled to view it.
GIGA - ULiège - FNRS
" Covid-19 is associated with a high risk of thrombotic disease, both in the venous and arterial circulations. As President of the Belgian Society on Thrombosis and Hemostasis (BSTH), I am coordinating the creation of national algorithms for thromboprophylaxis and anticoagulation of Covid-19 patients by a group of experts. These algorithms will be included in the Sciensano Covid-19 guidelines. "
Publication References: In preparation
Contact: Cécile Oury, PhD President of the Belgian Society on Thrombosis and Haemostasis Research Director F.R.S.-FNRS Head of the Laboratory of Cardiology GIGA-Cardiovascular Sciences University of Liège (B34) 1 Avenue de l'Hôpital 4000 Liège (Sart-Tilman) Belgium Tel: +32 (0)4 366 24 87 This email address is being protected from spambots. You need JavaScript enabled to view it.
UNamur
" In vitro studies will investigate the abilities of SARS-Cov-2 to enter various types of human neurons (cell lines and iPS-derived) and possible axoplasmic transport. In the meantime, analysis of post-mortem CNS and PNS samples from COVID patients would strengthen the hypothesis of SARS-Cov-2 neuro-tropism. "
Funding: CUR-FNRS (pending)
Contact: This email address is being protected from spambots. You need JavaScript enabled to view it.
UCLouvain, St-Luc
" We aim to characterize the reprogramming of structural cells of the lungs that are direct targets of the SARS-CoV-2, namely type 2 alveolar epithelial cells and endothelial cells, as well as their potential role in the induction of the (hyper)inflammatory phase of the disease leading to acute lung injury. The skills of our laboratory in lung and mucosal immunology research that are relevant to this field are (1) access to precious human lung tissue (e.g. from SARS-CoV-2 patients), (2) multiplex immunofluorescence staining and isolation of structural cells (e.g. alveolar epithelial cells, endothelial cells) from the human lung, as well as (3) their characterization using cell culture-based readouts and (in collab. with the UCL-CTMA) genetic sequencing. "
Funding: FNRS CUR, application submitted on 01-05-20.
Publication References: 1. Gohy ST, Hupin C, Fregimilicka C, Detry BR, Bouzin C, Gaide Chevronay H, Lecocq M, Weynand B, Ladjemi MZ, Pierreux CE, Birembaut P...
ULiège CEIB
" Expert services for Federal Agency of Drug and Medical products "
Contact: This email address is being protected from spambots. You need JavaScript enabled to view it.
Institut Jules Bordet, ULB - FNRS
" Cancer patients under active treatment are thought to be highly vulnerable with regards to the current pandemic of COVID-19 disease. Their management has drastically changed over the past weeks, as clinics have been forced to adapt their care strategies according to national guidelines, postponing all non-essential consultations and having patients avoid the clinic altogether as much as possible. However, it is currently unclear if cancer patients are indeed at a higher risk of developing COVID-19 disease, and if systemic oncological treatment contributes to more severe disease because of suppression of the immune system, or rather protects against fatal cytokine release storms and acute respiratory distress syndromes. This information is absolutely crucial for the safety assessment of using cancer treatments during the COVID-19 pandemic, and for the monitoring of cancer patients during this period. Therefore, this project is a non-interventional...
ULB - Royal Academy of Sciences, Letters and Fine Arts of Belgium
" Our study aims to investigate the impact on mental health and well-being of the people during the containment due to COVID-19 pandemic. More specifically some factors are analyzed such as animal ownership and the practice of artistic activities. An online survey was developped including validated psychological scales. "
Funding: Fondation Prince Laurent
Publication References: The results are currently under statistical analysis
Contact : Claude TOMBERG: This email address is being protected from spambots. You need JavaScript enabled to view it. Sophie PELLON : This email address is being protected from spambots. You need JavaScript enabled to view it. Claire Drogoz-Villegas : This email address is being protected from spambots. You need JavaScript enabled to view it. http://cognit.ulb.be/wordpress/
Comment: This research has been accepted by the Ethics committee Erasme Hospital (April 17, 2020)
DNAlytics
" Research projects : contributions to research projects with academics and hospital representatives (-omics data investigations, biomarkers and multi-marker indicators, stratification of populations, predictive models for diagnosis/prognosis, ... Development / production capabilities: internal processes and quality system compatible with ISO.13485 (medical devices). Skills and expertise: data sciences, machine learning and other technologies from artificial intelligence; statistics, bio-IT; model encapsulation into software, mobile apps or web platforms "
Funding: Prestations sub-contracted by lead researchers, or partnerships through regional/EU projects with public funding.
Publication References: Complete list on www.dnalytics.com/publications/
Contact : This email address is being protected from spambots. You need JavaScript enabled to view it.
FARAH - ULiège
" We are describing the evolution of the respiratory function after infection using whole-body plethysmography in a hamster model of SARS-CoV-2 pneumonia. Although the tropism of the virus for the upper respiratory tract is well documented, little is known about the pathophysiological mechanisms involved in the impairment of the respiratory function and the development of acute respiratory distress syndrome (ARDS) in some patients. There is a critical need for the development of noninvasive evaluation tools of the respiratory function over the disease course in order to develop therapeutic strategies aiming at specifically improving this function. Plethysmography is a noninvasive method allowing the quantitative evaluation of the lung volume and function. The selected plethysmographic parameters will allow a noninvasive monitoring of the lung function and lesions in the hamster model, permitting the screening of therapeutic molecules aiming at alleviating the...
Read more: Daniel Desmecht, Professor - Mutien Garigliany, Professor
FARAH - ULiège
" We recently showed that domestic cats can be spontaneously infected by SARS-CoV-2 and develop transient, yet severe, pneumonia. Similar reports in other countries confirmed the susceptibility of cats, ferrets, lions and tigers to the infection. Dogs can get infected but, apparenlty, subclinically. Beside the importance of these findings for veterinarians and animal health, a series of domestic or wild animal species might constitute a reservoir of SARS-CoV-2 and dramatically complicate the "uncontainment" process. Domestic cats, minks, ferrets, hamsters, dogs, tigers and lions were all shown to be naturally or (for some species) experimentally susceptible to SARS-CoV-2 infection. In addition, cats, minks, ferrets and hamsters were shown to be able to efficiently transmit the virus to in-contact animals. Little is known about the actual host range of the virus. It is critically needed to determine which domestic, peri-domestic (especially rodents) and wild animals can...
Read more: Daniel Desmecht, Professor - Mutien Garigliany, Professor
UCLouvain - FNRS
" We developed protocols to measure the interaction between single virus and living cells and monitor the effect of blocking molecule interfering with the virus binding. "
Contact: Dr. David Alsteens UCLouvain/ LIBST This email address is being protected from spambots. You need JavaScript enabled to view it.
