3D-Side S.A.
" "- 3D printing of swabs in SLS - 3D printing of valves - 3D printing of connectors for respiratory systems - Advice on guidelines on the manufacturing and post processing of such devices." "
Contact: Khanh TRAN DUY This email address is being protected from spambots. You need JavaScript enabled to view it.
Covartim
"In the global effort to help the healthcare professionals in the fight against the Covid pandemic, we are providing documents to help manufacturers that are not familiar with medical devices to properly document their work to help them in their product development and achieving compliance. These templates are derived from our technical file documentation and include some reference to guidances (mostly applicable in Belgium) for devices and accessories to answer to hospital products shortage."
Contact : Covartim www.covartim.be This email address is being protected from spambots. You need JavaScript enabled to view it.
UCLouvain
" I have been asked by the IATDMCT to pilot a review sumarizing the potential interactions that it could have between investigational COVID antivirals and immunosuppressants (used to avoid rejection in solid organ transplantation) "
Publication References: PubMed ID=32304488 Pharmacologic treatment of transplant recipients infected with SARS-CoV-2: considerations regarding therapeutic drug monitoring and drug-drug interactions. Ther Drug Monit. 2020 Apr 15. doi: 10.1097/FTD.0000000000000761. [Epub ahead of print]
Contact: This email address is being protected from spambots. You need JavaScript enabled to view it.
ULiège - FNRS - Royal Academy of Medicine of Belgium
" Massive infiltration of activated macrophages is associated with the development of a cytokine storm that leads to severe acute respiratory syndrome induced by SARS-CoV-2. Based on our results demonstrating the key role exerted by epigenetic regulation in the activity of macrophages, we propose to study the methyltransferase EZH2 in the pathogenesis induced by SARS-CoV-2. We have also shown that the PD-1 immune checkpoint is responsible for the macrophage anergy induced by the absence of EZH2. The goal of the project is to temper the excessive inflammatory responses associated with macrophages by interfering on the EZH2-PD-1 axis. "
Funding: Decision pending (FNRS Crédit Urgent de Recherche 40002642)
Publication References: - Inhibition of EZH2 methyltransferase decreases immunoediting of mesothelioma cells by autologous macrophages through a PD-1-dependent mechanism. Malik Hamaidia, Hélène Gazon, Clotilde Hoyos, Gabriela...
Erasme Hopital
" Nutritional assessment and support for optimal rehabilitation following COVID 19 critical illness "
Funding: NA
Contact: NA
ULB - FNRS
" Computational analysis of the impact of SARS-CoV-2 on the renin-angiotensin system. "
Funding: FNRS
Contact: This email address is being protected from spambots. You need JavaScript enabled to view it. This email address is being protected from spambots. You need JavaScript enabled to view it.
ULiège
" Collective production of 3D printed face shields and mask clips to be distributed to health care professionals. About 400 face shields were produced and distributed within a month. Collaboration involving CARE-FEPEX and FVM skill lab. "
Contact: Ludovic Martinelle This email address is being protected from spambots. You need JavaScript enabled to view it. 04 366 40 39
CUB-Erasme
" "Background: There are no currently approved therapeutics for COVID-19 disease. This disease causes significant morbidity and mortality. Main Objectives: The overall objective of the study is to evaluate the clinical efficacy and safety of different investigational therapeutics relative to the control arm in patients hospitalized with COVID-19 patients. The primary endpoint is subject clinical status (on a 7-point ordinal scale) on Day 15. The secondary objectives are to evaluate clinical, and virological efficacy, and safety of different investigational therapeutics as compared to the control arm. Study design: This is a prospective, worldwide, adaptive, randomized, controlled, open study comparing 4 different treatments for COVID-19. The protocol is based on the WHO Master protocol of the Solidarity trial. The DisCoVeRy protocol previews more data collection and lower dosage regimens of Hydroxychloroquine than in the SOLIDARITY trial. Randomization is performed by...
CUB-Erasme
" "a. Background Coronavirus disease 2019 (COVID-19) is a respiratory tract infection caused by a new coronavirus SARS CoV-2, responsible for the current pandemic, causing a lot of morbidity and mortality. Most people with COVID-19 develop mild respiratory illness (stage I). However, in a sub-group of patients (+/- 15%) there are increasing respiratory symptoms and persistent fever (stage II). Patients may develop acute lung injury (hypoxia, and bilateral opacities on chest computed tomography (CT-scan)), requiring hospitalisation. A further 5% of patients develop stage III disease, requiring admission to the intensive care unit (ICU) due to acute respiratory distress syndrome (ARDS), sepsis and septic shock, and multi-organ failure. As patients progress from stage I to stage III, there are increasing signs of systemic hyper-inflammatory response, reflected by high levels of cytokines, C-reactive protein (CRP), ferritin, and lymphopenia. Different viral, bacterial, and...
ULiège, CIRM, FARAH
" Several natural products (i.e. lycorine, glycyrrhizine, extracts of Pelargonium, Echinacea, Sambucus,...) have shown activity against coronaviruses. Several plants have been used in Chinese Medicine to treat patients with COVID-19. The objective of this project is to evaluate several natural products against SARS-COV2 in vitro and confirm their potential for further development. "
Funding: Own funding.
Contact: Prof Michel FREDERICH https://www.cirm.uliege.be This email address is being protected from spambots. You need JavaScript enabled to view it.
Bordet Institute
" On April 11th, 2020, four patients hospitalized for more than 7 days developed fever some of them respiratory symptoms compatible with Covid-19 infection and were detected positive for SARS-CoV2. A 5th patient was also detected positive , had minor symptoms and was admitted 2 days earlier for collecting PBSC As a consequence of this mini-outbreak a screening of healthcare workers at this Unit revealed 2 staff members positive for SARS-CoV2. Severe acute respiratory distress syndrome Coronavirus 2(SARS-CoV2), causing Covid19 pandemic is rapidly spreading from person-to-person, via respiratory droplets, direct contact with mucous membranes or indirect contact through touching infected surfaces and then touching own eyes, nose or mouth. Airborne transmission after generated aerosols (intubation, bronchoscopy, tracheal aspiration,…) have been previously reported for other Coronaviruses(SARS-CoV1, MERS) and has been postulated for SARS-Cov2. In critical units such as the...
UCLouvain/Cliniques universitaires Saint-Luc
" COVID-19 pandemic has an important impact on the health care provided by the anesthesiologists. Different societies of anesthesiology have provided guidelines and recommendations on how to manage patients who have been tested positive for COVID-19 or suspected to be infected. It is therefore important to know whether these guidelines have been implemented or were possible to be implemented. Otherwise patients who are presenting COVID-19 often show pulmonary complications. The airway management and the ventilation management of these patients can be therefore challenging and can possibly influence their outcome. It is thus important to obtain a large database with information about the characteristics of these patients, how these patients have been managed and their in-hospital outcome. Information regarding the correct implementation of guidelines is as well necessary for future guidance of health care providers. "
Funding: None
Contact...
ULB - Royal Academy of Medicine of Belgium
" The project aims at understanding why men are more affected than women. Compelling evidences indicate sex-bias in SARS-CoV2 with male representing the majority of severe cases requiring intensive care. Excessive inflammatory symptoms attributed mainly to cytokine storm is the hall-mark of disease progress. We ask whether differences in genetic fitness between male and female patients could contribute to sex-bias and we focus, in particular, on potential role of microRNAs in fine tuning the type and magnitude of the inflammatory response "
Funding: Current application to FNRS IRIS research
Publication References: - Chamekh M, M Deny, M Romano, et al. Differential Susceptibility to Infectious Respiratory Diseases between Males and Females Linked to Sex-Specific Innate Immune Inflammatory Response. Front Immunol. 2017; 8: 1806. - Casimir, G. J., Lefèvre, N., Corazza, F et al. J. Sex and inflammation in respiratory diseases : a clinical...
ULiège
" There is a critical need for therapeutic solutions against SARS-CoV-2. Before implementing innovative treatments in human medicine, a first screening of the antiviral or immunomodulatory activity should be performed by in vitro and in vivo methods. To this aim, we developed in vitro (cell culture) and in vivo (hamsters and mice) models of SARS-CoV-2 infection. We developed an in vitro (cell culture) and in vivo (hamsters and mice) to screen antiviral or immunomodulatory molecules, in partnership with colleagues from the ULiège hospital and the GIGA research center. We also validate the inactivation protocols to facilitate the diagnostic workflow, in partnership with the Federal task force. "
Funding: Currently no funding. We applied to the "Crédits urgents de recherche" call.
Contact: Mutien Garigliany, DVM, PhD, Dipl. ECVP Professor Department of Pathology Faculty of Veterinary Medicine Centre for Fundamental and Applied Research for Animals & Health (FARAH) Liège...
Read more: Mutien Garigliany, Professor - Daniel Desmecht, Professor
FARAH - ULiège
" As of today, one of the most promising therapeutic solutions against COVID-19 is the use of convalescent plasma. A subset of the antibodies present in this plasma are able to bind the surface proteins of the virus, chiefly the Spike (attachment) protein, and to neutralize the ability of viral particles to infect permissive cells. Upon request of the Red Cross and ULiège CHU hospital, we developed seroneutralization assays to determine the titers in neutralizing antibodies of convalescent plasma. In collaboration with KU Leuven (Rega) and ITM Antwerp, we just completed an interlaboratory ring test. We screen convalescent plasmas on a routine basis for the Croix Rouge and Rode Kruis. Only plasmas with a titer in neutralizing antibodies above the cut-off value will be used therapeutically. The scarcity of the scientific literature on the subject (only a few studies on the therapeutic use of convalescent plasmas are currently available) make it difficult to fix a cut-off...
Read more: Mutien Garigliany, Professor - Daniel Desmecht, Professor
