ULiège, CHU - Royal Academy of Medicine of Belgium
" Nous faisons face à une pandémie d'infection COVID-19. Ce virus pathogène est source de complications pulmonaires aggravant fortement le pronostic de nos patients. De nos jours, tant les mécanismes physiopathologiques en cause que les marqueurs de sévérité de l'atteinte restent indéterminés. Il apparaît donc comme urgent de pouvoir identifier des marqueurs diagnostiques, pronostiques et prédictifs pour nos patients. Dans ce contexte, plusieurs voies rapidement explorables nous apparaissent comme critiques. Le but final de cette étude est de contribuer à une prise en charge plus ciblée des patients porteurs d'une infection au SRAS-Cov-2. "
Funding: Fonds Léon Frederic
Publication References: Dix publications représentatives : 1) Prevention of murine radiogenic thymic lymphomas by tumor necrosis factor or by marrow grafting. HUMBLET C, GREIMERS R, DELVENNE P, DEMAN J, BONIVER J, DEFRESNE MP. J Natl Cancer Inst 88 (1996), 824-831. IF = 14.159 2) Dendritic cells induce the death of human papillomavirus-transformed keratinocytes in an in vitro model of cervical (pre)neoplastic lesions. HUBERT P, GIANNINI SL, VANDERPLASSCHEN A, GREIMERS R, FRANZEN-DETROOZ E, JACOBS N, BONIVER J, DELVENNE P. FASEB J 15 (2001), 2521-2523. IF = 8.817 3) Epithelial metaplasia : an inadequate environment for anti-tumour immunity? DELVENNE P, HUBERT P, JACOBS N. Trends Immunol. 25 (2004):169-173. IF = 13.075 4) Defensins induce the recruitment of dendritic cells in cervical human papillomavirus-associated (pre)neoplastic lesions formed in vitro and transplanted in vivo. HUBERT P, HERMAN L, MAILLARD C, CABERG JH, NIKKELS A, PIERARD G, FOIDART JM, NOEL A, BONIVER J, DELVENNE P. FASEB J 21 (2007), 2765-2775. IF = 7.064 5) NF-kB-induced KIAA1199 promotes survival through EGFR signaling. SHOSTAK K*, ZHANG X*, HUBERT P*, GÖKTUNA SI, JIANG Z, KLEVERNIC I, HILDEBRAND J, RONCARATI P, HENNUY B, LADANG A, SOMJA J, GOTHOT A, CLOSE P, DELVENNE P**, CHARIOT A**. Nat Commun. (2014) Nov 4;5:5232. doi: 10.1038/ncomms6232. (*: first co-authors; **: senior co-authors) IF = 10.742 6) Unique recurrence patterns of cervical intraepithelial neoplasia following excision of the squamo-columna junction. HERFS M, SOMJA J, HOWITT B, SUAREZ-CARMONA M, KUSTERMANS G, HUBERT P, DOYEN J, GOFFIN F, KRIDELKA F, CRUM CP, DELVENNE P. Int J Cancer136 (2015), 1043-1052. IF = 6.198 7) Monoclonal antibodies against GARP/TGF-β1 complexes inhibit the immunosuppressive activity of human regulatory T cells in vivo. CUENDE J, LIÉNART S, DEDOBBELEER O, VAN DER WONING B, DE BOECK G, STOCKIS S, HUYGENS C, COLAU D, SOMJA J, DELVENNE P, HANNON M, BARON F, DUMOUTIER L, RENAULD JC, DE HAARD H, SAUNDERS M, COULIE P, LUCAS S. Science Translational Medicine (2015) doi: 10.1126/scitransimed.aaa 1983. IF = 14.414 8) Proteomic signatures reveal a dualistic and clinically relevant classification of anal canal carcinoma. HERFS M, LONGUESPÉE R, QUICK CM, RONCARATI P, SUAREZ-CARMONA M, HUBERT P, LEBEAU A, BRUYERE D, MAZZUCCHELLI G, SMARGIASSO N, BAIWIR D, LAI K, DUNN A, OBREGON F., YANG EJ, DE PAUW E, CRUM CP, DELVENNE P. J Pathol 241 (2017), 522-533. IF = 7.381 9) A dualistic model of primary anal canal adenocarcinoma with distinct cellular origins, etiologies, inflammatory microenvironments and mutational signatures. HERFS M, RONCARATI P, KOOPMANSCH B, PEULEN O, BRUYERE D, LEBEAU A, HENDRICK E, HUBERT P, PONCIN A, PENNY W, PIAZZON N, MONNIEN F, GUENAT D, MOUGIN C, PRETET JC, VUITTON L, SEGERS K, LAMBERT F, BOURS V, DE LEVAL L, VALMARY-DEGANO S, QUICK C, CRUM C, DELVENNE P. Br J Cancer 118 (2018), 1302-1312. Doi : 10.1038/s41416-018-0049-2. IF =6.176 10) Proteomics highlights common and distinct pathophysiological processes associated to ileal and colonic ulcers in Crohn's disease. PIERRE N, SALÉE C, MASSOT C, BLÉTARD N, MAZZUCCHELLI G, SMARGIASSO N, MORSA D, BAIWIR D, DE PAUW E, REENAERS C, VAN KEMSEKE C, LOLY JP, DELVENNE P, MEUWIS MA, LOUIS E. Journal of Crohn's and Colitis (2019). Doi: 10.1093/ecco-jcc/jjz130. IF = 7.827
Contact: "NOM : DELVENNE PRENOM : Philippe ADRESSE POSTALE : Anatomie Pathologique – CHU Liège TELEPHONE (bureau + personnel): 04.366.24.10 E-MAIL (bureau + personnel): This email address is being protected from spambots. You need JavaScript enabled to view it. SERVICE/DEPARTEMENT (CHU/ULIEGE): Anatomie Pathologique – CHU Liège "