D-tek s.a
" "Multiplex Immuno-Dot technology for COVID-19 serological investigation The Multiplex serological technology, developed since 1995 in D-tek (www.d-tek.be), is dedicated to the profiling of the human antibody response to different immunogens, in a single test. It has various applications in laboratory diagnostics, as well as medical and pharmaceutical research (companion-diagnostics). The technology finds an obvious application for the COVID-19 serological investigation, as the antibody response to the SARS-CoV-2 infection is known to be complex, with multi-epitope targeting, and needs to be better understood. In a typical test (ongoing development), various recombinant SARS-CoV-2 antigens are coated on a membrane strip at different spot positions. The assay is designed to map, in one single test, any patient antibody recognizing any of these protein structures. The test procedure is a classical enzyme immunoassay that can be processed from 10µl of patient's serum or plasma, either manually or automated (results in 1h), and is intended to be used as: • A routine diagnostic test in clinical laboratories. • A research tool to: - map the antibody response to SARS-CoV-2 infection and analyse the spectrum of antibodies' specificities. - better understand the variability in the outcome of infection in different individuals. - distinguish between binding antibodies (Nucleocapsid) and neutralizing antibodies (S, RBD). - Stratify the risk regarding protective immunity. - Perform longitudinal serological studies of the dynamics and duration of the different antibodies. • A ""companion-diagnostic"" test for evaluation of the results of vaccine trials, and differential identification of vaccinated vs naturally immunized individuals (anti-N and anti-S differential response). • A ""companion-diagnostic"" test for the development of therapeutic antibodies. X The project is the development of a multiplex serological test for profiling the human antibody response to SARS-CoV-2 infection" "
Funding: None (Self-funding)
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