GIGA-Institute, ULiège - FNRS
" In this project, we study the epitranscriptomic regulation of the SARS-CoV-2. Based on analyses of the viral genome, we investigate the cellular machineries required for the viral replicative cycle. Our goal is to identify possible viral vulnerabilities that can be exploited for the development of innovative anti-viral therapeutic strategies. We investigate possible new therapeutic opportunities based on the analyses of the viral genomic organization and evolution. We speculate that specific cellular machineries are needed to support the viral replicative cycle. Our goal is uncover new antiviral therapeutic strategies based on the viral epitranscriptomic regulation, mRNA translation and protein expression. "
Funding: WELBIO & ULIEGE
Publication References: Rapino F, Delaunay S, Rambow F, Zhou Z, Tharun L, De Tullio P, Sin O, Shostak, Schmitz S, Piepers J, Ghesquière B, Karim L, Charloteaux B, Jamart D, Florin A, Lambert C, Rorive A, Jerusalem G, Leucci E, Dewaele M, Vooijs M, Leidel SA, Georges M, Voz M, Peers B, Büttner R, Marine JC, Chariot A and Close P. Codon-specific translation reprogramming promotes resistance to targeted therapy. Nature, 2018 Jun;558(7711):605-609
Contact: Pierre CLOSE, Ph.D. FNRS - WELBIO Head of Lab of Cancer Signaling GIGA-institute Université de Liège CHU, B34, Tour GIGA (+2) B-4000 Liège Tél: +32 4 366 2923 Fax: +32 4 366 4534 This email address is being protected from spambots. You need JavaScript enabled to view it. http://www.gigalcs.uliege.be @gigacancersignaling
Comment: Collaborative efforts: - Michel Georges - Vincent Bours - Daniel Desmechts & Mutien Garigliani