ULB, Hôpital Erasme - FNRS
Lung injury, endothelial dysfunction and the role of RAAS during SARS-CoV-2 invection. " The first case of a person infected with SARS-Cov-2 virus can be tracked back on November the 17th, 2019, in China. On March 11, 2020, the World Health Organization (WHO) declared COVID-19 outbreak a pandemic. On April 13, COVID-19 is affecting 210 countries and territories worldwide, about 2 million positive cases have been officially declared along with 115.000 deaths. The real number of infected and deaths is scarily higher, considering that up to 65% people are asymptomatic and thus, not tested. The percentage of patients with COVID-19 needed for intensive care unit (ICU) varied from 5 to 32% in Wuhan, China. It was up to 9% in Lombardy, Italy. According to available data from Lombardy, 99% of patients admitted to the ICU needed respiratory support (88% invasive ventilation, 11% non invasive ventilation). In this unprecedented time, while SARS-Cov-2 virus is halting the Planet, freezing health care systems worldwide and taking its toll at a terrifying pace, scientific research is, more than ever, the most powerful weapon we have to face this mortal enemy. The present investigation is aimed to 1. to test the prognostic utility of pneumoproteins, Clara cell-16 proteine and the surfactant protein D, for the prediction of respiratory deterioration in patients with COVID-related acute lung injury. 2. to compare transcutaneous oxygen saturation and transcutaneous carbon dioxide with finger oxygen saturation and to test the prognostic utility of transcutaneous oxygen and carbon dioxide saturations for the prediction of respiratory deterioration in patients with COVID-related acute lung injury. 3. To test the prognostic utility and the phyiopathological role of the Renin-Angiotensin system in the progression of the disease 4. to study the impact of SARS-CoV-2 infection on endothelial function assessed through arterial stiffness and skin microcirculatory blood flow "
Funding: Accademic fundings
Contact: Sofia Morra, MD, PhD fellow FNRS aspirant Service de Cardiologie Hôpital Erasme This email address is being protected from spambots. You need JavaScript enabled to view it.