Institut Jules Bordet, ULB - FNRS
" Cancer patients under active treatment are thought to be highly vulnerable with regards to the current pandemic of COVID-19 disease. Their management has drastically changed over the past weeks, as clinics have been forced to adapt their care strategies according to national guidelines, postponing all non-essential consultations and having patients avoid the clinic altogether as much as possible. However, it is currently unclear if cancer patients are indeed at a higher risk of developing COVID-19 disease, and if systemic oncological treatment contributes to more severe disease because of suppression of the immune system, or rather protects against fatal cytokine release storms and acute respiratory distress syndromes. This information is absolutely crucial for the safety assessment of using cancer treatments during the COVID-19 pandemic, and for the monitoring of cancer patients during this period. Therefore, this project is a non-interventional...

Read more: Christos Sotiriou, FNRS Research Director

Erasme Hospital
" Objectifs : L'épidémie du coronavirus a eu des conséquences délétères sur la santé mentale de la population générale1,2. Aucune étude ne s'est encore penchée sur l'impact psychologique du coronavirus sur les proches des patients ayant été infectés par le covid-19. Cette étude permet de comparer les proches de patients survivants ayant séjourné ou n'ayant pas séjourné en soins intensifs, des proches de patients décédés. Méthodologie : Les familles (N=200) dont le proche a séjourné en soins intensifs ou en unité COVID à l'hôpital Erasme seront contactées par téléphone et invitées à compléter des questionnaires en ligne au minimum 1 mois après la sortie d'hospitalisation de leur proche, ou après son décès, et ensuite 6 mois après la première évaluation. Les variables psychologiques qui seront évaluées sont : (1) la qualité de vie (The Mc Gill Quality of Life Questionnaire), les symptômes anxieux et dépressifs (Hospital Anxiety and Depression Scale, HADS), les...

Read more: Delphine Canivet, PhD

ULiège and CHU de Liège
" BACKGROUND The SARS-CoV2 or COVID-19 infection is unique in terms of its speed of spread, the importance of structural medical reorganization, the length of resuscitation stays sometimes required, the diversity of the affected population, especially young or fragile subjects, and the impacts on physical and mental health generated by this pandemic and the prolonged confinement of populations. Muscle damage related to immobility, inflammation, corticosteroids, hypoxemia associated with pulmonary and cardiac damage, and metabolic damage (undernutrition), all sometimes linked to the infection, suggests weak or major functional repercussions, already described in SARS patients. Thus, the patients most affected by COVID-19 require acute hospital management and sometimes complex rehabilitation management. Retrospective studies of the functional capacities of patients with SARS of viral origin show the persistence of functional impairment at a distance from the...

Read more: Jean-François Kaux, Professor

LHUB-ULB - Royal Academy of Medicine of Belgium
" "The purpose of this study is to map the healthcare workers exposure risk in Saint-Pierre University Hospital by combining molecular methods with serological assays. In summary, the short-term objective is threefold: (1) Provide an estimate of the sero-prevalence at baseline among high-risk health care workers (2) Determine prospectively the incidence of new SARS-CoV-2 infections among high-risk health care workers (3) Estimate the healthcare worker exposure to the virus by serological data to help our five partner hospitals in their day-to-day management of the ongoing pandemic The mid-term objectives are: (1) Establish an accurate mapping of the spread of the virus among our population allowing to identify the chain of transmission, (2) Identify predictive immunological markers of susceptibility to infection and disease severity to inform vaccine strategies and, (3) Establish solid diagnosis algorithm that will help adequate lockdown...

Read more: O. Vandenberg, Pr. - N. Clumeck, Pr. - C. Montesinos, Pr. - N. Dauby, MD, PhD - C. Gilles, MD - C....

ULiège, CHU - Royal Academy of Medicine of Belgium
" Nous faisons face à une pandémie d'infection COVID-19. Ce virus pathogène est source de complications pulmonaires aggravant fortement le pronostic de nos patients. De nos jours, tant les mécanismes physiopathologiques en cause que les marqueurs de sévérité de l'atteinte restent indéterminés. Il apparaît donc comme urgent de pouvoir identifier des marqueurs diagnostiques, pronostiques et prédictifs pour nos patients. Dans ce contexte, plusieurs voies rapidement explorables nous apparaissent comme critiques. Le but final de cette étude est de contribuer à une prise en charge plus ciblée des patients porteurs d'une infection au SRAS-Cov-2. "
Funding: Fonds Léon Frederic
Publication References: Dix publications représentatives : 1) Prevention of murine radiogenic thymic lymphomas by tumor necrosis factor or by marrow grafting. HUMBLET C, GREIMERS R, DELVENNE P, DEMAN J, BONIVER J, DEFRESNE MP. J Natl Cancer Inst 88 (1996), 824-831. IF...

Read more: Ph. DELVENNE, FNRS Research Director / Chef de service Anatomie pathologique - J. GUIOT, Chef de...

HUDERF and ULB
" Role of Children in Sars-Cov-2 transmission, Heath Care Worker protection, Paediatric epidemiology and disease burden "
Funding: FNRS funding under assessment.
Contact: Prof Pierre Smeesters Academic Children Hospital Queen Fabiola Molecular Bacteriology Laboratory, ULB This email address is being protected from spambots. You need JavaScript enabled to view it.

UMONS and Ambroise-Paré Hospital Mons
" Predictive plasma signature of the clinical behavior of COVID-19 patients. The clinical presentation of COVID-19 infection varies from mild to asymptomatic to pneumonia, which can be complicated by severe respiratory failure and/or cardiovascular, renal, hepatic and cutaneous involvement. The understanding of such a polymorphism is very incomplete and the prognosis is difficult. Several tracks involving inflammatory reactions are currently favored to better explain this disease. In particular, the significant increase in plasma cytokines IL2, IL7, IL10, GSCF, IP10, MCP1, MIP1A and TNFα, known as "cytokine storm", seems to be significantly associated with the ARDS and multi-organ onsets. In this context, IL6 seems to play an important role and targeted treatments against this cytokine seem promising. Also, the infection of endothelial cells by the coronavirus causing endothelium inflammation have been suggested as one of the fundamental...

Read more: Stéphane CARLIER, Prof - Jean-Marie COLET, Prof - Fabrice JOURNE, Dr - Sven SAUSSEZ, Prof- Vincent...