CHU-Liège 
" The University Hospital of Liège (CHULiège) has developed a diagnostic capability to detect the SARS-CoV-2 by RT-PCR in response to the need for more capacity testing in Belgium from March 2020. Indeed, from February 2020, clinical COVID-19 cases were already detected in Belgium thanks to the Reference laboratory for respiratory viruses in KULeuven (Reflab). However, it appeared rapidly evident that the capacity of the Reflab could not be further enhanced. Therefore Belgian university and non-university hospital laboratories started to develop RT-PCR assays which sensitivity were first validated by the Reflab. CHULiège developed an in house SARS-CoV-2 RT-PCR assay following an adapted version of the Charité Hospital (1) protocol with the aid of the Antwerp University Hospital Microbiology lab and the Reflab. We have chosen to include two targets: the E and RNA-dependent RNA polymerase (RdRP) genes. From the 6th March, we were able to run the test and since this date we run...

Read more: Marie-Pierre HAYETTE, The RT-PCR diagnostic platform of CHU Liège for the detection of SARS-CoV-2

ULB (centre ACTE) et Fondation SUSA Mons
Confinement lié au Covid-19 : le vécu de la famille et de l'enfant avec autisme." For almost two months, Belgian families have been confined at home because of the Covid-19 pandemic. This lockdown dramatically changed the daily life of families, especially those living with an autistic child, because social life and relationships are at the very heart of the autistic functioning. In some cases, changing daily habits and routines, closing of schools, stopping interventions and outdoor activities led to an increase of behavioral disorders and significantly impaired the quality of life of autistic people and their family. But, on the other hand, some families report an improvement of their child’s behavior, potentially due to a decrease of usual social demands. In order to understand how families with an autistic child dealt during this lockdown period, we conducted an on-line survey. To date, more than 250 French-speaking Belgian families...

Read more: Marielle WEYLAND, Speech Therapist, PhD Student.

ULiège + Mesylab SRL
" How to securely return to normalcy at work? All countries consider to lift the lockdown, but few have executed it. There are no "best practices". Questions abound: What are the risks? What are the most effective measures? Will communities follow? What are the consequences for our individual lives? Who decides how to proceed? AIMS OF THE PROJECT GIGA aims at defining the best possible approach to opening up again by involving its members. Your opinion matters. GIGA has sought assistance in conducting this real time experiment from political scientists, philosophers, lawyers and medical doctors. "
Contact: This project is supported by the GIGA office and is coordinated by the ad hoc Advisory Committee made up of expert political scientists in participation (Dr. F. Thoreau, Dr. C. Parotte, Dr. P. Delvenne, Dr. C. Fallon), a political and ethicist philosopher (Dr. F. Caeymaex) and doctors (Dr. Y. Beguin, Dr. G. Darcis).

ULiège
" Collective production of 3D printed face shields and mask clips to be distributed to health care professionals. About 400 face shields were produced and distributed within a month. Collaboration involving CARE-FEPEX and FVM skill lab. "
Contact: Ludovic Martinelle This email address is being protected from spambots. You need JavaScript enabled to view it. 04 366 40 39

CUB-Erasme
" "Background: There are no currently approved therapeutics for COVID-19 disease. This disease causes significant morbidity and mortality. Main Objectives: The overall objective of the study is to evaluate the clinical efficacy and safety of different investigational therapeutics relative to the control arm in patients hospitalized with COVID-19 patients. The primary endpoint is subject clinical status (on a 7-point ordinal scale) on Day 15. The secondary objectives are to evaluate clinical, and virological efficacy, and safety of different investigational therapeutics as compared to the control arm. Study design: This is a prospective, worldwide, adaptive, randomized, controlled, open study comparing 4 different treatments for COVID-19. The protocol is based on the WHO Master protocol of the Solidarity trial. The DisCoVeRy protocol previews more data collection and lower dosage regimens of Hydroxychloroquine than in the SOLIDARITY trial. Randomization is performed by...

Read more: Maya Hites, Associate Professor

CUB-Erasme
" "a. Background Coronavirus disease 2019 (COVID-19) is a respiratory tract infection caused by a new coronavirus SARS CoV-2, responsible for the current pandemic, causing a lot of morbidity and mortality. Most people with COVID-19 develop mild respiratory illness (stage I). However, in a sub-group of patients (+/- 15%) there are increasing respiratory symptoms and persistent fever (stage II). Patients may develop acute lung injury (hypoxia, and bilateral opacities on chest computed tomography (CT-scan)), requiring hospitalisation. A further 5% of patients develop stage III disease, requiring admission to the intensive care unit (ICU) due to acute respiratory distress syndrome (ARDS), sepsis and septic shock, and multi-organ failure. As patients progress from stage I to stage III, there are increasing signs of systemic hyper-inflammatory response, reflected by high levels of cytokines, C-reactive protein (CRP), ferritin, and lymphopenia. Different viral, bacterial, and...

Read more: Maya Hites, Associate Professor

BECARV SA
" BECARV supplies and install solution and equipement for labs, such as modular biosafety cabinets, air purifier for containment of a room, filter units, etc "
Contact: www.becarv.be Michaël Jeanty This email address is being protected from spambots. You need JavaScript enabled to view it.

ULiège, CIRM, FARAH
" Several natural products (i.e. lycorine, glycyrrhizine, extracts of Pelargonium, Echinacea, Sambucus,...) have shown activity against coronaviruses. Several plants have been used in Chinese Medicine to treat patients with COVID-19. The objective of this project is to evaluate several natural products against SARS-COV2 in vitro and confirm their potential for further development. "
Funding: Own funding.
Contact: Prof Michel FREDERICH https://www.cirm.uliege.be This email address is being protected from spambots. You need JavaScript enabled to view it.

ULiège, CHU, Obstetrics and Gynecology - Royal Academy of Medicine of Belgium
" The primary objective of the project is to assess the risk of maternal-fetal transmission of the SARS-CoV-2 virus. The secondary objectives are to analyze the impact of COVID-19 infection on the course of pregnancy as well as that of the newborn. This is a prospective study of a positive COVID-19 pregnant patients cohort in a population of 2,500 patients who give birth in the Gynecology-Obstetrics Department at CHR-Liège. Samples will be taken from the mother, the newborn and from the placenta during childbirth from patients who were diagnosed with COVID-19 during pregnancy or when they were admitted to the delivery unit. Obstetric and neonatal repercussions will be analyzed. "
Funding: Fondation Leon Fredericq
Contact: Pr Michelle Nisolle This email address is being protected from spambots. You need JavaScript enabled to view it.

Bordet Institute
" On April 11th, 2020, four patients hospitalized for more than 7 days developed fever some of them respiratory symptoms compatible with Covid-19 infection and were detected positive for SARS-CoV2. A 5th patient was also detected positive , had minor symptoms and was admitted 2 days earlier for collecting PBSC As a consequence of this mini-outbreak a screening of healthcare workers at this Unit revealed 2 staff members positive for SARS-CoV2. Severe acute respiratory distress syndrome Coronavirus 2(SARS-CoV2), causing Covid19 pandemic is rapidly spreading from person-to-person, via respiratory droplets, direct contact with mucous membranes or indirect contact through touching infected surfaces and then touching own eyes, nose or mouth. Airborne transmission after generated aerosols (intubation, bronchoscopy, tracheal aspiration,…) have been previously reported for other Coronaviruses(SARS-CoV1, MERS) and has been postulated for SARS-Cov2. In critical units such as the...

Read more: Mickael Aoun, Infectiologist

UCLouvain - Royal Academy of Sciences, Letters and Fine Arts of Belgium
" International research project about the environmental/personal/family/economic factors influencing the risk of parental burnout during the COVID-19 crisis. Link to the Belgian French-speaking version version: https://uclpsychology.co1.qualtrics.com/jfe/form/SV_02LE6m47hjSYtr7 Creation of a hotline to help parents cope with their children and work during the COVID-19 crisis (SOS Parents: 0471/414.333) Project made possible thanks to the gracious help of 42 volunteering psychologists. Participation as expert in the media (written press, radio, TV). "
Funding: No funding
Contact: Hotline: SOS Parents (0471/414.333) Website: Advice to prevent parental burnout during the crisis: https://www.burnoutparental.com/ 

UCLouvain/Cliniques universitaires Saint-Luc 
" COVID-19 pandemic has an important impact on the health care provided by the anesthesiologists. Different societies of anesthesiology have provided guidelines and recommendations on how to manage patients who have been tested positive for COVID-19 or suspected to be infected. It is therefore important to know whether these guidelines have been implemented or were possible to be implemented. Otherwise patients who are presenting COVID-19 often show pulmonary complications. The airway management and the ventilation management of these patients can be therefore challenging and can possibly influence their outcome. It is thus important to obtain a large database with information about the characteristics of these patients, how these patients have been managed and their in-hospital outcome. Information regarding the correct implementation of guidelines is as well necessary for future guidance of health care providers. "
Funding: None
Contact...

Read more: Mona Momeni, MD, PhD

ULB - Royal Academy of Medicine of Belgium
" The project aims at understanding why men are more affected than women. Compelling evidences indicate sex-bias in SARS-CoV2 with male representing the majority of severe cases requiring intensive care. Excessive inflammatory symptoms attributed mainly to cytokine storm is the hall-mark of disease progress. We ask whether differences in genetic fitness between male and female patients could contribute to sex-bias and we focus, in particular, on potential role of microRNAs in fine tuning the type and magnitude of the inflammatory response "
Funding: Current application to FNRS IRIS research
Publication References: - Chamekh M, M Deny, M Romano, et al. Differential Susceptibility to Infectious Respiratory Diseases between Males and Females Linked to Sex-Specific Innate Immune Inflammatory Response. Front Immunol. 2017; 8: 1806. - Casimir, G. J., Lefèvre, N., Corazza, F et al. J. Sex and inflammation in respiratory diseases : a clinical...

Read more: Mostafa Chamekh, Professor (coordinator of the project) - Georges Casimir, Professor - Francis...

ULiège 
" There is a critical need for therapeutic solutions against SARS-CoV-2. Before implementing innovative treatments in human medicine, a first screening of the antiviral or immunomodulatory activity should be performed by in vitro and in vivo methods. To this aim, we developed in vitro (cell culture) and in vivo (hamsters and mice) models of SARS-CoV-2 infection. We developed an in vitro (cell culture) and in vivo (hamsters and mice) to screen antiviral or immunomodulatory molecules, in partnership with colleagues from the ULiège hospital and the GIGA research center. We also validate the inactivation protocols to facilitate the diagnostic workflow, in partnership with the Federal task force. "
Funding: Currently no funding. We applied to the "Crédits urgents de recherche" call.
Contact: Mutien Garigliany, DVM, PhD, Dipl. ECVP Professor Department of Pathology Faculty of Veterinary Medicine Centre for Fundamental and Applied Research for Animals & Health (FARAH) Liège...

Read more: Mutien Garigliany, Professor - Daniel Desmecht, Professor

FARAH - ULiège 
" As of today, one of the most promising therapeutic solutions against COVID-19 is the use of convalescent plasma. A subset of the antibodies present in this plasma are able to bind the surface proteins of the virus, chiefly the Spike (attachment) protein, and to neutralize the ability of viral particles to infect permissive cells. Upon request of the Red Cross and ULiège CHU hospital, we developed seroneutralization assays to determine the titers in neutralizing antibodies of convalescent plasma. In collaboration with KU Leuven (Rega) and ITM Antwerp, we just completed an interlaboratory ring test. We screen convalescent plasmas on a routine basis for the Croix Rouge and Rode Kruis. Only plasmas with a titer in neutralizing antibodies above the cut-off value will be used therapeutically. The scarcity of the scientific literature on the subject (only a few studies on the therapeutic use of convalescent plasmas are currently available) make it difficult to fix a cut-off...

Read more: Mutien Garigliany, Professor - Daniel Desmecht, Professor